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发布时间:2024-04-25 22:22:34 来源:文档文库
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琥珀酸索利那新治疗女性患者膀胱过度活动症的有效性及安全性的研究
摘要目的研究琥珀酸索利那新治疗女性患者膀胱过度活动症的有效性及安全性。方法90例
女性膀胱过度活动症患者,随机分为对照组及试验组,各45例。对照组采取酒石酸托特罗定片治疗,试验组给予琥珀酸索利那新治疗,比较两组治疗前及治疗后2、4周膀胱过度活动症症状表(OABSS)评分以及不良反应情况。结果两组治疗后OABSS评分均优于治疗前(P<0.05);治疗4周后试验组OABSS评分(4.5±1.87)分优于对照组(5.6±1.78)分,差异有统计学意义(P<0.05)。试验组不良反应率为6.67%,低于对照组的22.22%,差异有统计学意义(P<0.05)。结论使用琥珀酸索利那新治疗女性膀胱过度活动症临床疗效高,不良反应率低,值得推广。
关键词琥珀酸索利那新;女性患者膀胱过度活动症
ResearchofeffectivenessandsafetybysolifenacinsuccinateinthetreatmentoffemaleoveractivebladderpatientsLIUYan-xia,LUDan,LIJing.DepartmentofPharmacy,DalianCityFriendshipHospital,Dalian116001,
China
【Abstract】ObjectiveToresearcheffectivenessandsafetybysolifenacinsuccinateinthetreatmentoffemaleoveractivebladderpatients.MethodsAtotalof90femaleoveractivebladderpatientswererandomlydividedintocontrolgroupandexperimentalgroup,with45casesineachgroup.Thecontrolgroupreceivedtolterodinetartratetabletsfortreatment,andtheexperimentalgroupreceivedsolifenacinsuccinatetablets.Overactivebladdersymptomscores(OABSS)andadversereactionswerecomparedbetweenthetwogroupsbeforeandin2and4weeksaftertreatment.ResultsBothgroupshadbetterOABSSscoresaftertreatmentthanthosebeforetreatment(P<0.05).After4weeksoftreatment,theexperimentalgrouphadbetterOABSSscoreas(4.5±1.87)pointsthan(5.6±1.78)pointsofthecontrolgroup,andtheirdifferencehadstatisticalsignificance(P<0.05).Theexperimentalgrouphadlowerincidenceofadversereactionsas6.67%than22.22%ofthecontrolgroup,andtheirdifferencehadstatisticalsignificance(P<0.05).ConclusionImplementofsolifenacinsuccinateshowshighclinicaleffectandlowincidenceofadversereactionsintreatingfemaleoveractivebladder,anditisworthpromoting.
【Keywords】Solifenacinsuccinate;Femaleoveractivebladderpatients
膀胱过度活动症的主要临床表现为尿急症状,尿动力学表现为尿肌过度活动或尿道-膀胱功能障碍。该病的发生率女性高于男性,并且随年龄增长而增加,
其发病率增高,给患者生活带来极大的痛苦以及经济负担。目前,